Endocrine Abstracts

The estrogen receptor (ER) plays an important role in breast cancer development and progression. Hypoxia was shown to modulate the level of ERα expression and induce ligand-independent transcriptional activation of ERα, which may be intimately associated with the biology of breast carcinomas. Given that phosphorylation affects the transcriptional activity and stabilization of ERα, we examined the changes in phosphorylation of ERα under hypoxic conditions. H...

Introduction: There are many reports that vascular and/or heart valve calcification is good predictor for low bone mineral density. I investigated whether benign calcification of breast can also well predict low bone mineral density.Methods/design: I have reviewed and analyzed the records of 91 women with age more than 50 years old among patients examined bone mineral density and breast mammography from January through December 2010. The lowest value of ...

Atypical manifestations of hyperthyroidism include hematological, cardiovascular, dermatological manifestation. Especially single lineage abnormalities such as anemia (34%), leukopenia (5.8%), thrombocytopenia (3.3%) are reported, but pancytopenia is a rare presentation of hyperthyroidism. The suspected etiologic mechanisms include ineffective hematopoiesis, reduction in blood cell life span, autoimmune process, toxicity of thyroid hormone.We report a ca...

The metabolic features of Polycystic ovary syndrome (PCOS) can vary based on the definition used. The aim of this study is to compare the metabolic characteristics of PCOS according to the phenotypes from various diagnostic criteria and help to establish a optimal diagnostic criteria.Subjects with PCOS defined by the NIH criteria (n=494) and the Rotterdam criteria (n=568) and regular cycling non-hirsuite control women (n=1000) were r...

Insulin resistance is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of insulin resistance and inflammatory response. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and insulin resistance and inflammatory marker in obese women with PCOS and controls.We recruited 50 obese women with PCOS (age 25±5 years, BMI 27.5±2.3...

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...

Objective. The aims of our study were to utilise a combination of high fidelity phenotyping, microarray gene expression profiling and conserved synteny mapping between rodent and human genomes to identify genetic determinants underlying human hypertension.Methods. We used the stroke-prone spontaneously hypertensive rat (SHRSP) and a congenic strain (SP.WKYGla2c*) produced by introgressing a quantitative trait locus responsible for blood pressure regulation on rat chromosom...

Objectives: We investigated cardiovascular and all-cause mortality in patients who underwent gastrectomies for early gastric cancer (EGC), and analyzed the changes in metabolic parameters in these patients after surgery.Background: Bariatric surgery, including gastric banding and gastric bypass, effectively induces weight loss and resolves cardiovascular comorbidities in obese patients.Methods: 2477 patients who underwent gastrecto...

Introduction: Activating somatic mutation of the BRAF gene (V600E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (32–87%) in various races by different methods.In this study, we report the genetic analysis of BRAF mutation in a Korean cohort of 211 PTC by peptide nucleic acid clamp real-time PCR.Methods: PNA clamp real-time PCR was applied for BRAF analysis ...